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BPC-157 first appeared in the early 1990s, when European researchers wondered why some stomach ulcers healed quickly while others didnt, Flynn McGuire, a physical medicine and rehabilitation resident at the University of Utah who is about to enter a sports medicine fellowship, tells Outside Run

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Other strategies targeting insulin resistance support this rationale: metformin has shown antitumor effects in preclinical models and improved outcomes in diabetic cancer patients (36, 37), whereas exogenous insulin use has been associated with a modestly increased risk of gastrointestinal tumors (38, 39)

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Clinics offering FDA-approved brands or oral options are better aligned with that preference